ea0070aep1105 | Hot topics (including COVID-19) | ECE2020
Kvaratskhelia Tamar
, Abzianidze Elene
, Kakulia Mzeona
, Surmava Sandro
, Asatiani Ketevan
, Kvaratskhelia Eka
Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...